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![Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitits: A case-control study. Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitits: A case-control study.](https://eiu.education/wp-content/uploads/2016/08/Clinical-significance-of-interleukin-1-genotype-in-smoking-patients-as-a-predictor-of-peri-implantitits-A-case-control-study.jpg)
Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitits: A case-control study.
Background: Interleukin-1 (IL-1) is a proinflammatory cytokine that plays an important role in the pathogenesis of periodontitis, and so it might be useful to detect high-risk cases of peri-implantitis. It has been reported that IL-1 polymorphisms and smoking habit have a synergic effect, increasing the incidence of peri-implantitis. The aim of the present study was to evaluate the relationship between IL-1 gene polymorphisms and peri-implantitis in smoking patients. Material and Methods: A case-control study was performed in 27 patients with peri-implantitis and 27 patients
with healthy implants. All patients included were smokers. IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C were identified by polymerase chain reaction (PCR) amplification in order to establish a relation between these variables and the presence of peri-implantitis. A bivariate analysis was performed and odds-ratio (OR) were calculated. Results: The incidence of peri-implantitis was significantly higher in patients with previous history of periodontitis (p=0.024; OR=10.9). Both groups were similar regarding IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C genotypes. No increased risk in heavy smokers with IL-1 polymorphism was found.